Seizures and Epilepsy in Autism Spectrum Disorder
Richard E. Frye, M.D., Ph.D.
Most treatments used with Autistic children are not FDA approved
Children with autism spectrum tend to have more seizures than children without Autism.
Two age peaks for the seizures
- Before age 5
- Adolescence
Causes of seizures in Autism
- Brain Malformations
- Onset at Birth
- Microcephaly
- Development Delay
- Metabolic Disorders
- Mitochondrial Disorders
- Cerebral folate deficiency
Treatments of Seizure in Autism
- Antiepileptic Medications (there have not been any controlled studies for autism)
- Levetiracetam - double blind trial did not show any significant change in behavior
- Divalproex Sodium - Open label trial showed some improvement
- Lamotrigine - trial did not show any improvement
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